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KMID : 1134820140430111695
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Journal of the Korean Society of Food Science and Nutrition
2014 Volume.43 No. 11 p.1695 ~ p.1700
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Skin Whitening and Anti-Wrinkle Effects of Extract from Jubak of Oriental Herbal Liquor
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Lee Su-Min
Lee Sang-Jin
Kwon Yi-Young
Baek Sang-Hoon
Kim Jong-Sik
Sohn Ho-Yong
Shin Woo-Chang
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Abstract
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Oriental herbal liquor (Yakju) is a type of Korean traditional alcoholic beverage that uses Nuruk and oriental herbs for fermentation. The purpose of this study was to develop cosmetic ingredients using Jubak, which is a by-product of alcoholic fermentation of oriental herbal liquor. To investigate antioxidant, whitening, and anti-aging effects of Jubak, we prepared extract of Jubak and its solvent fractions. Ethyl acetate fraction (KSD E4-3) showed the most prominent free radical [1,1-diphenyl-2-picrylhydrazyl (DPPH)] scavenging activity (SC50: 0.75 mg/mL). KSD E4-3 significantly inhibited in vitro mushroom tyrosinase activity (IC50: 0.82 mg/mL) and reduced the melanin contents in mouse melanoma melanocyte, B16F10 cells. KSD E4-3 down-regulated protein expression of tyrosinase related proteins (TRP)-1, -2, which play key roles in melanogenesis. For anti-aging effects, inhibition of matrix metalloproteinase (MMPs) expression was evaluated using human keratinocyte, HaCaT cells. Treatment of HaCaT cells with KSD E4-3 reduced expression of MMP-1, -2, -9 and inhibited proteolytic activities of MMP-2, -9. These results suggest that KSD E4-3 induces down-regulation of cellular melanogenesis and protects against photoaging induced by UVB-induced damage. Thus KSD E4-3 could potentially be a valuable cosmetic ingredient.
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KEYWORD
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antioxidant, anti-melanogenesis, anti-wrinkle, oriental herbal liquor, Jubak
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